MOB1A Polyclonal Antibody for Human(Homo sapiens) | EIAab.comMOB1A Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > MOB1A(Gene name) > Human

MOB1A (Gene name),

MOB kinase activator 1A (Protein name ), MOB1A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MOB1A(C2orf6;MOB4B;MOBK1B;MOBKL1B);

Protein name:

MOB kinase activator 1A;

Alternative:

Mob1 homolog 1B;Mob1 alpha(Mob1A);Mps one binder kinase activator-like 1B;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.

Function:

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

216

Sequence:

50:

100:

150:

200:

216:

LAPLQELIEK | LGSKDR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.602092

MIM:

609281

Pfam:

PF03637

STRING:

9606.ENSP00000379364

SMR:

Q9H8S9

KEGG:

hsa:55233

Uniprot:

Q9H8S9

FOR

ELISA Kit for Human MOB kinase activator 1A

Cat.:

E2914r

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MSDS:

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Packing:

96T

ELISA Kit for Human MOB kinase activator 1A

Cat.:

E2914h

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MSDS:

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96T

ELISA Kit for Human MOB kinase activator 1A

Cat.:

E2914m

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96T

CLIA Kit for Human MOB kinase activator 1A

Cat.:

U2914h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human MOB kinase activator 1A

Cat.:

U2914m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human MOB kinase activator 1A

Cat.:

U2914r

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human MOB kinase activator 1A

Cat.:

P2914Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MOB kinase activator 1A

Cat.:

P2914Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MOB kinase activator 1A

Cat.:

P2914Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human MOB kinase activator 1A

Protein for Human MOB kinase activator 1A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human MOB1."
Kagaya S. , Kotani S. , Todokoro K.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Characterization of the human Mob-1 like proteins."
Florindo C.S. , Tavares A.A.
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Embryo.
tissue: Ovary.
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
6.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-8;ACETYLATION AT SER-2
tissue: Platelet.
7.

"Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein."
Bichsel S.J. , Tamaskovic R. , Stegert M.R. , Hemmings B.A.
J. Biol. Chem.279:35228-35235(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH STK38 AND STK38L
8.

"MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation."
Praskova M. , Xia F. , Avruch J.
Curr. Biol.18:311-321(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-12 AND THR-35 BY STK3/MST2 AND STK4/MST1
9.

"Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1."
Hirabayashi S. , Nakagawa K. , Sumita K. , Hidaka S. , Kawai T. , Ikeda M. , Kawata A. , Ohno K. , Hata Y.
Oncogene27:4281-4292(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-74 AND THR-181;INTERACTION WITH STK38 AND STK3/MST2
10.

"Molecular characterization of human homologs of yeast MOB1."
Chow A. , Hao Y. , Yang X.
Int. J. Cancer126:2079-2089(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LATS1 AND LATS2;TISSUE SPECIFICITY
11.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways."
Stavridi E.S. , Harris K.G. , Huyen Y. , Bothos J. , Verwoerd P.-M. , Stayrook S.E. , Pavletich N.P. , Jeffrey P.D. , Luca F.C.
Structure11:1163-1170(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 33-216;PARTIAL PROTEIN SEQUENCE;IDENTIFICATION BY MASS SPECTROMETRY;ZINC-BINDING

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